HNF1A Deficiency Impairs Beta-cell Fate, Granule Maturation and Function /
Mutations in HNF1A cause Maturity Onset Diabetes of the Young type 3, the second most frequent form of diabetes caused by single gene mutation. We generated human stem cell-derived pancreatic endocrine cells with clinically pathogenic mutations in HNF1A and show that HNF1A deficiency impairs endocri...
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Format: | Thesis Book |
Language: | English |
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[New York, N.Y.?] :
[publisher not identified],
2019
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Internet
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