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|a 1461345715
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|a 10.1007/978-1-4613-4571-8
|2 doi
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|a (OCoLC)840282793
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|z (OCoLC)922906581
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|a 572
|2 23
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|a Katsoyannis, P. G
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|a The Chemistry of Polypeptides :
|b Essays in Honor of Dr. Leonidas Zervas /
|c edited by P.G. Katsoyannis
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|a Boston, MA :
|b Springer US,
|c 1973
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
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|a online resource
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|a 1 The Scientific Work of Leonidas Zervas -- 2 Active Esters and the Strategy of Peptide Synthesis -- I. Introduction -- II. The Development of Active Esters -- III. Active Esters in Stepwise Syntheses -- IV. Active Esters in Solid-Phase Peptide Synthesis -- V. Conclusions -- References -- 3 The Facilitation of Peptide Synthesis by the Use of Picolyl Esters -- I. Introduction : The "Functional Handle" -- II. 4-Picolyl Esters of?-Amino Acids -- III. Use of 4-Picolyl Esters for the Facilitation of Peptide Synthesis -- IV. Conclusions from Recent Experience -- References -- 4 On Cysteine and Cystine Peptides -- I. Introduction -- II. S-Protection of Cysteine During Peptide Synthesis: Transformation of S-Protected Cysteine Peptides to Cystine Peptides -- III. Unsymmetrical Cystine Peptides -- References -- 5 The Tosyl and Related Protecting Groups in Amino Acid and Peptide Chemistry -- I. Introduction -- II. Introduction of Tosyl Groups -- III. General Properties of Tosylamino Acids -- IV. Removal of Tosyl and Related Protecting Groups -- V. Tosylamino Groups in Carboxyl Protection and Carboxyl Activation -- VI. Tosyl Derivatives in Amino Acid Chemistry -- VII. Tosyl Protecting Groups in Peptide Synthesis -- VIII. Analytical Uses of Arenesulfonyl Derivatives -- IX. Sulfonyl Derivatives Other Than Tosyl -- X. Conclusion -- References -- 6 Tactics for Minimal Protection in Peptide Synthesis -- I. The Concept of the Minimal Use of Protecting Groups -- II. Indispensable Protection -- III. Conclusion -- References -- 7 Peptide Synthesis and the Specificity of Proteinases -- 8 Structural Studies of Naturally Occurring Cyclic Polypeptides at Rockefeller University -- 9 The Conformations of Cyclopeptides in Solution -- I. Introduction -- II. General Principles of Composite Physicochemical Study of the Solution Conformation of Cyclopeptides -- III. Cyclohexapeptides -- IV. Valinomycin -- V. Enniatins -- VI. Gramicidin S -- VII. Antamanide -- VIII. Conclusion -- References -- 10 Survey of the Synthetic Work in the Field of the Bacterial Cell Wall Peptides -- I. Introduction -- II. Stereospecific Preparation of Meso-diaminopimelic Acid Derivatives -- III. Synthesis of Meso-diaminopimelic Acid-Containing Peptide Subunits of the Escherichia coli Cell Wall Peptidoglycan -- IV. Synthesis of?-Branched Isoglutaminyl and Lysyl Peptides of the Staphylococcus aureus Cell Wall Peptidoglycan -- V. Synthesis of Linear and?-Branched Glutamyl and Lysyl Peptides of the Micrococcus lysodeikticus Cell Wall Peptidoglycan -- VI. Conclusions -- References -- 11 Intracellular Proteolysis and Its Demonstration with Synthetic and Natural Peptides and Proteins as Substrates -- I. Introduction -- II. The Concept of Proteolysis -- III. Synthetic Substrates for Protease Determinations -- IV. Autoproteolysis of Organs -- V. Qualitative and Quantitative Differentiation of Autoproteolysis by Use of Synthetic Substrates -- VI. Autoproteolysis of the Cell Components and Proteolytic Interactions Between Them -- VII. Proteolytic Enzyme Activity of Lysosomes Toward the Cell's Own Cytosol Proteins in Comparison to Foreign Proteins and Synthetic Peptides -- VIII. Significance of Enzymatic Reductive Cleavage of Disulfide Bridges for Intracellular Proteolysis -- IX. Conclusions -- References -- 12 Synthesis of Human ACTH and Its Biologically Active Fragments -- I. Introduction -- II. Synthesis of Human ACTH -- III. Synthesis of Sequence Homologs of Corticotropins -- IV. Biological Activity of the Synthetic Peptide Fragments -- V. Conclusions -- References -- 13 Synthesis of Pure Polypeptide Hormones with Full Biological Activity -- I. Introduction -- II. Glucagon -- III. [15-Leucine]-Human Gastrin I -- IV. Secretin -- V. Concluding Remarks -- References -- 14 Neurohypophyseal Hormones : Old and New Slants on the Relationship of Chemical Structure to Biological Activity -- 15 Use of Polymeric Reagents in the Synthesis of Linear and Cyclic Peptides -- I. Introduction -- II. Polymeric Reagents and Their Potential Use in Organic Synthesis -- III. Polymeric Reagents in Peptide Synthesis -- IV. Use of Polymeric Active Esters of Blocked Amino Acids in Peptide Synthesis -- V. Polymer Condensing Agents -- VI. Cyclic Peptides -- VII. Concluding Remarks -- References -- 16 Solid-Phase Peptide Synthesis -- I. Introduction -- II. The Solid-Phase Idea -- III. Summary and Conclusions -- References -- 17 Monitoring in Solid-Phase Peptide Synthesis -- I. Introduction -- II. Monitoring of the Coupling Reaction -- III. Monitoring of the Deprotection Step -- IV. Discussion -- References -- 18 Need for Solid-Phase Thinking in Solid-Phase Synthesis -- I. Introduction -- II. The Nonsolid State of the Solid Phase -- III. The Solid-Phase Peptide -- IV. Solid-Phase Analysis -- V. Conclusions -- References
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|a 1 The Scientific Work of Leonidas Zervas.- 2 Active Esters and the Strategy of Peptide Synthesis.- I. Introduction.- II. The Development of Active Esters.- III. Active Esters in Stepwise Syntheses.- IV. Active Esters in Solid-Phase Peptide Synthesis.- V. Conclusions.- References.- 3 The Facilitation of Peptide Synthesis by the Use of Picolyl Esters.- I. Introduction : The "Functional Handle"--II. 4-Picolyl Esters of?-Amino Acids.- III. Use of 4-Picolyl Esters for the Facilitation of Peptide Synthesis.- IV. Conclusions from Recent Experience.- References.- 4 On Cysteine and Cystine Peptides.-
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|a Biochemistry
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|a Life sciences
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|a Amino Acids, Peptides, and Proteins
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|a Chemicals and Drugs
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|a Peptides
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|a Biochemistry
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|a Life sciences
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|z 9781461345732
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