High-resolution NMR techniques in organic chemistry /
From the initial observation of proton magnetic resonance in water and in paraffin, the discipline of nuclear magnetic resonance has seen unparalleled growth as an analytical method. Modern NMR spectroscopy is a highly developed, yet still evolving, subject which finds application in chemistry, biol...
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| Format: | Book |
| Language: | English |
| Published: |
Amsterdam ; New York :
Pergamon,
1999
Amsterdam ; New York : c1999 Amsterdam ; New York : 1999 |
| Edition: | 1st ed |
| Series: | Tetrahedron organic chemistry series ;
v. 19 Tetrahedron organic chemistry series v. 19 Tetrahedron organic chemistry series ; v. 19 Tetrahedron organic chemistry series v. 19 |
| Subjects: |
Table of Contents:
- Introducing high-resolution NMR
- Practical aspects of high-resolution NMR
- One-dimensional techniques
- Correlations through the chemical bond 1, Homonuclear shift correlation
- Correlations through the chemical bond 2, Heteronuclear shift correlation
- Separating shifts and couplings : J-resolved spectroscopy
- Correlations through space : the nuclear Overhauser effect
- Experimental methods
- note: Ch. 1 Introduction
- Ch. 2 Introducing high-resolution NMR
- Ch. 3 Practical aspects of high-resolution NMR
- Ch. 4 One-dimensional techniques
- Ch. 5 Correlations through the chemical bond I: Homonuclear shift correlation
- Ch. 6 Correlations through the chemical bond II: Heteronuclear shift correlation
- Ch. 7 Separating shifts and couplings: J-resolved spectroscopy
- Ch. 8 Correlations through space: The nuclear Overhauser effect
- Ch. 9 Experimental methods
- Ch. 1 Introduction
- Ch. 2. Introducing high-resolution NMR
- Ch. 3. Practical aspects of high-resolution NMR
- Ch. 4. One-dimensional techniques
- Ch. 5. Correlations through the chemical bond I: Homonuclear shift correlation
- Ch. 6. Correlations through the chemical bond II: Heteronuclear shift correlation
- Ch. 7. Separating shifts and couplings: J-resolved spectroscopy
- Ch. 8. Correlations through space: The nuclear Overhauser effect
- Ch. 9. Experimental methods.
- The development of high-resolution NMR
- Modern NMR and this book
- Applying modern NMR techniques
- Introducing High-resolution NMR
- Nuclear spin and resonance
- The vector model and pulse excitation
- Time and frequency domains
- Spin relaxation
- Mechanisms for relaxation
- Practical Aspects of High-resolution NMR
- An overview of the NMR spectrometer
- Data acquisition and processing
- Preparing the sample
- Preparing the spectrometer
- Spectrometer calibrations
- Spectrometer performance tests
- One-dimensional Techniques
- The single-pulse experiment
- Spin decoupling methods
- Spectrum editing with spin-echoes
- Sensitivity enhancement and spectrum editing
- Observing quadrupolar nuclei
- Correlations through the Chemical Bond I: Homonuclear Shift Correlation
- Introducing the second dimension
- Correlation spectroscopy (COSY)
- Practical aspects of 2D NMR
- Coherence and coherence transfer
- Gradient-selected spectroscopy
- Alternative COSY sequences
- Total correlation spectroscopy (TOCSY)
- Correlating dilute spins: INADEQUATE
- Correlations through the Chemical Bond II: Heteronuclear Shift Correlation
- Sensitivity
- Heteronuclear single-bond correlation spectroscopy
- Heteronuclear multiple-bond correlation spectroscopy
- Traditional X-detected correlation spectroscopy
- Separating Shifts and Couplings: J-resolved Spectroscopy
- Heteronuclear J-resolved spectroscopy
- Homonuclear J-resolved spectroscopy
- "Indirect" homonuclear J-resolved spectroscopy
- Correlations through Space: The Nuclear Overhauser Effect
- Part I Theoretical Aspects
- Definition of the NOE
- Steady-state NOEs
- Transient NOEs
- Rotating-frame NOEs
- Part II Practical Aspects
- Measuring steady-state NOEs: NOE difference
- Measuring transient NOEs: NOESY
- Measuring rotating-frame NOEs: ROESY
- Measuring heteronuclear NOEs
- Experimental considerations
- Experimental Methods
- Composite pulses
- Broadband decoupling and spin-locks
- Selective excitation and shaped pulses
- Solvent suppression
- Recent methods