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|a 3787
|b Henry Stewart Talks
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|a (OCoLC-M)903195087
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|a (Sirsi) a11083439
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|a HSTalks
|c HSTalks
|d CSt
|d UtOrBLW
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| 100 |
1 |
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|a Alon, Uri,
|d 1969-
|4 spk
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| 245 |
1 |
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|a Evolutionary tradeoffs and the geometry of gene expression space
|h [electronic resource] /
|c Uri Alon
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| 260 |
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|a London :
|b Henry Stewart Talks,
|c 2014
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| 300 |
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|a 1 online resource (1 streaming video file (36 min.) :
|b color, sound)
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| 490 |
1 |
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|a Systems biology,
|x 2056-452X
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| 500 |
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|a Animated audio-visual presentation with synchronized narration
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| 500 |
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|a Title from title frames
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|a Contents: Organisms, tissues and molecules often need to perform multiple tasks -- Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff -- We study this using the concept of Pareto optimality from engineering and economics -- Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons -- At the vertices of these polygons are phenotypes that specialize at a single task -- We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems.
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| 506 |
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|a Access restricted to subscribers
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| 538 |
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|a Mode of access: World Wide Web
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|a System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v2.1+, iPhone 4+ (iOS v5.x+), iPad 2+ (iOS v5.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
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| 650 |
0 |
0 |
|a Bioinformatics
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| 650 |
0 |
0 |
|a Biological models
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| 650 |
0 |
0 |
|a Computational biology
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| 650 |
0 |
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|a Evolution (Biology)
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| 650 |
0 |
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|a Fossils
|x anatomy & histology
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| 650 |
0 |
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|a Gene expression
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| 650 |
0 |
0 |
|a Mathematical optimization
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| 650 |
0 |
0 |
|a Molecular biology
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| 650 |
0 |
0 |
|a Morphology (Animals)
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| 650 |
0 |
0 |
|a Phenotype
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| 650 |
0 |
0 |
|a Systems biology
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| 650 |
0 |
2 |
|a Beak
|x anatomy & histology
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| 650 |
0 |
2 |
|a Evolution, Molecular
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| 650 |
0 |
2 |
|a Genes, Bacterial
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| 650 |
0 |
2 |
|a Genetic Fitness
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| 650 |
0 |
2 |
|a Models, Statistical
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| 650 |
0 |
2 |
|a Selection, Genetic
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| 830 |
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