Genomic disorders : the genomic basis of disease /
It is now abundantly clear that architectural features of the human genome can lead to DNA rearrangements that cause both disease and behavioral traits. In Genomic Disorders: The Genomic Basis of Disease, distinguished experts and pioneers in the field of genomics and genome rearrangements summarize...
| Other Authors: | , |
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| Format: | Book |
| Language: | English |
| Published: |
Totowa, N.J. :
Humana Press,
c2006
Totowa, N.J. : ©2006 |
| Subjects: |
| Summary: | It is now abundantly clear that architectural features of the human genome can lead to DNA rearrangements that cause both disease and behavioral traits. In Genomic Disorders: The Genomic Basis of Disease, distinguished experts and pioneers in the field of genomics and genome rearrangements summarize and synthesize the tremendous amount of data now available in the postgenomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to evolution and explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection. Comprehensive and clinically relevant, Genomic Disorders: The Genomic Basis of Disease offers genome and clinical genetics researchers not only an up-to-date survey of genome architecture, but also details those rearrangements that can be the underlying cause or basis of many human traits and disorders |
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| Physical Description: | 1 online resource (xvii, 426 p.) : ill. (some col.) 1 online resource (xvii, 426 pages) : illustrations (some color) |
| Bibliography: | Includes bibliographical references and index |
| ISBN: | 1280831995 1588295591 1597450391 9781280831997 9781588295590 9781597450393 |