Muscle aging : inclusion-body myositis and myopathies /
For neurologists, neuroscientists, gerontologists, internists, general physicians, nurses, and physical therapists, Askanas and Engel (neurology and pathology, U. of Southern California) compile 16 articles on muscle aging and sporadic inclusion-body myositis, as well as hereditary inclusion-body my...
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| Other Authors: | , |
| Format: | Book |
| Language: | English |
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Chichester, West Sussex :
Wiley-Blackwell,
2012
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| Summary: | For neurologists, neuroscientists, gerontologists, internists, general physicians, nurses, and physical therapists, Askanas and Engel (neurology and pathology, U. of Southern California) compile 16 articles on muscle aging and sporadic inclusion-body myositis, as well as hereditary inclusion-body myopathies. Specialists in neurology, gerontology, genetics, and other disciplines from the US, Europe, Israel, Japan, and Australia focus on various aging-associated neuromuscular disorders at the cellular and clinical levels, described through histochemical abnormalities seen in biopsies and clinical vignettes of representative aging patients. They emphasize treatable and not-yet-treatable conditions associated with aging, and stress that aging is not a valid explanation for the cause of neuromuscular symptoms. They discuss mitochondrial changes in aging, protein degradation in aging cells and mitochondria, the therapeutic implications of human muscle protein metabolism in relation to exercise and aging, and sporadic inclusion-body myositis, the molecular mechanisms involved in its pathogenesis, inflammatory and autoimmune features, clinical symptoms, physical findings, and diagnostic investigations and criteria. They address genetic aspects of hereditary inclusion-body myopathies, animal models, potential treatment, clinical features and epidemiology, the effects of mutations, and inclusion-body myopathy associated with Paget disease and frontotemporal dementia. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com) |
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| Physical Description: | xii, 250 pages, 8 unnumbered pages of color plates : illustrations ; 26 cm |
| Bibliography: | Includes bibliographical references and index |
| ISBN: | 1405196467 9781405196468 |