Table of Contents:
  • Keratinizing Lesions That Warn of Impending or Actual Invasion. CIS With Atypical Differentiation ("Differentiated CIS"). The Buds of Early Stromal Invasion. An Alternate Warning of Impending Invasion: Micronucleoli. The Cytologic Recognition of Early Stromal Invasion. Controversies Over Depth and Vascular Space Invasion
  • 5. Invasive Squamous Cell Carcinoma. Recapitulation. From Early Stromal Invasion to Microinvasive Carcinoma. Morphologic Criteria of Invasive Carcinoma. Histology and Classification of Squamous Cell Carcinomas. Diagnostic Pitfalls. Detection of Cancer in the Endocervical Canal. Eight Illustrative Cases. Radiation Effect
  • 6. Adenocarcinoma and Its Precursors. Adenocarcinoma in Situ and Microinvasive Adenocarcinoma. Invasive Adenocarcinoma of the Cervix
  • 7. Problems with Biopsies and Smears. The Inadequate Cervical Biopsy and the False Negative Report. The Inadequate Pap Smear
  • Foreword / Leopold G. Koss
  • 1. Morphology, Cytology and Repair. Basic Morphology and Cytology of the Uterine Cervix. The Transitional Zone: Its Origin and Development into Squamous Metaplasia. The Healing of Erosions by Squamous Epithelium, and a Word of Caution. Two Benign Abnormalities of Squamous and Glandular Cervical Epithelium That can be Confused With Malignancy
  • 2. Intraepithelial Precursors to Invasive Squamous Cell Carcinoma. Historical Perspective. HPV Effect, Dysplasia and CIS: Definitions and Criteria. Classification Systems to be Evaluated and Reconciled. Problems and Pitfalls in Diagnosis: Shades of Gray
  • Summary and Review of Diagnostic Criteria
  • 3. Human Papillomavirus (HPV) Infection: Its Importance, Morphologic Expression, Relevance to Neoplasia, and Methods of Viral Detection and Typing / Gerard J. Nuovo. Molecular Hybridization Analysis for HPV. Morphologic Expression of HPV Infection
  • 4. Early Stromal Invasion. The Meaning of "Differentiation"